Cell Fate Plug and Play: Direct Reprogramming and Induced Pluripotency
نویسندگان
چکیده
Building on the discovery that MyoD expression reprograms fibroblasts into muscle, three papers (Vierbuchen et al., 2010; Ieda et al., 2010; Szabo et al., 2010) recently reported the reprogramming of fibroblasts into neurons, cardiomyocytes, and blood cell progenitors without first passing the cells through a pluripotent state. Here we discuss the advantages and challenges of harnessing this direct reprogramming method for regenerative medicine.
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عنوان ژورنال:
- Cell
دوره 145 شماره
صفحات -
تاریخ انتشار 2011